Activin levels correlate with lymphocytic infiltration in epithelial ovarian cancer
INHBA expression is elevated within EOC, correlating with worse survival, with activin protein levels correlating with specific immune infiltration. Our findings suggest that activin-A may play a role in suppressing anti-tumor immunity in EOC, highlighting its potential as a therapeutic target.
Authors
- Zainab Shonibare (ORCID: https://orcid.org/0000-0002-9140-7679)
- Andrea G. Kahn (ORCID: https://orcid.org/0000-0003-3905-0390)
- Alex Seok Choi (ORCID: https://orcid.org/0000-0002-5410-6906)
- Rebecca C. Arend (ORCID: https://orcid.org/0000-0003-2108-3426)
- Emily Faith Page (ORCID: https://orcid.org/0000-0002-1282-116X)
- Elizabeth Evans (ORCID: https://orcid.org/0000-0002-8855-5873)
- Karthikeyan Mythreye (ORCID: https://orcid.org/0000-0001-5478-0098)
Institutions
- University of Alabama (US)
- University of Alabama at Birmingham (US)
Publication Details
- Journal
- Cancer Medicine
- Published
- 2024-09-01
- DOI
- https://doi.org/10.1002/cam4.7368
- Citations
- 5
- Primary Topic
- Cancer-related molecular mechanisms research
- Type
- article
- Field-Weighted Citation Impact
- 1.43
Funders
- Division of Cancer Prevention, National Cancer Institute
- National Cancer Institute