F050 Comparing the one touch stockings of cambridge and Zindametrix’s Tower-Z as components of the HD-CAB in SHIELD-HD

<h3>Background</h3> Cognitive decline is a feature of HD. The Huntington’s Disease Cognitive Assessment Battery (HD-CAB) was developed as a fit-for-purpose cognitive assessment battery for HD clinical trials. The HD-CAB consists of six cognitive assessments: the Symbol Digit Modalities Test, Trail Making Test B, Emotion Recognition, Paced Tapping, Hopkins Verbal Learning Test – Revised, and One Touch Stockings of Cambridge (OTS). In 2021, the HD-CAB version of the OTS was discontinued. Therefore, Zindametrix developed the Tower-Z task (TZ) as a potential replacement for the OTS. The OTS and TZ tests were included in Triplet Therapeutic’s longitudinal, observational study, SHIELD-HD. <h3>Aim</h3> The purpose of this poster is to describe the analyses we intend to conduct to determine if the TZ test is a psychometrically sound replacement for the OTS in the HD-CAB. <h3>Methods</h3> 52 participants in SHIELD-HD completed the OTS and TZ at weeks 96 and 120. 10 participants completed the tasks at both time points and 42 participants completed the tasks at one of the two time points. <h3>Proposed Analyses</h3> Using the data from these participants, we intend to assess the (a) relationship between the two tests using the test-retest reliability of the OTS as the context for the interpretation of those estimates, (b) patterns of relationships the OTS and TZ shared with other tests in the HD-CAB, and (c) the comparability of HD-CAB overall composite scores when either the OTS or TZ are used in the calculation of the composite. <h3>Conclusion</h3> Through the proposed analyses we intend to evaluate the comparability of the TZ and OTS.