F081 A naturalistic assessment of lifestyle in Huntington’s disease; results from the DOMINO-HD study

<h3>Background</h3> The onset and progression of Huntington’s Disease (HD) can be influenced by variations in genetics, but also by a variety of environmental factors. There is evidence to suggest that aspects of lifestyle (physical activity, sleep and nutrition) may have a role to play in disease progression. <h3>Aims</h3> To assess the feasibility of conducting a 12-month linked study of lifestyle and clinical outcomes in people with HD. <h3>Methods</h3> Enroll-HD participants were recruited into a 12-month observational study within ± 8 weeks of their annual Enroll-HD assessment. At baseline, participants completed questionnaires relating to physical activity, nutrition and sleep. Each participant received a Fitbit Charge 4 which they were required to wear for the duration of the study and upload data via data synchronisation with their smartphone. Clinical outcomes were collected at baseline and 12 months at annual Enroll-HD visits and were obtained via a specific data request. Data were analysed descriptively in relation to pre-specified feasibility outcomes. <h3>Results</h3> We recruited 82 participants who provided a complete baseline dataset for analysis, with 75 participants providing follow-up data at 12 months. Retention, physical activity, sleep and nutrition data completion, and linkage to Enroll-HD data met pre-specified feasibility thresholds. It was not feasible to link genetic data to Enroll-HD data. <h3>Conclusions</h3> We have demonstrated that it is possible to conduct a longitudinal study of lifestyle in people with HD and established methods for assimilating digital sensor and specific outcome data alongside clinical measures captured via Enroll-HD.