F068 Depression, Suicidal ideation, and substance abuse in Huntington’s disease (HD): comparing university of Washington (UW) enroll participants to global enroll and non-HD populations

<h3>Background</h3> HD is a neurodegenerative condition characterized by changes in movement, cognition, and psychological health. Patients frequently present with depression and suicidal ideation (SI). <h3>Aims</h3> 1. Determine whether levels of depression and SI at our Enroll site are commensurate with those of the Global Enroll community and non-HD populations. 2. Examine the relationship between substance abuse and depression/SI among UW Enroll participants. <h3>Methods</h3> Information on substance abuse and psychiatric health was collected during Enroll visits. Prevalence of depression, SI, drug abuse, and alcohol abuse was calculated for gene-positive (CAG≥40) and reduced penetrance individuals (CAG=36–39). Using proportion Z-score testing for comparative analysis, we calculated p-values (p &lt;0.05) to determine statistical significance when comparing UW site variables (n=211) with Global Enroll-HD datasets (2018⁵, 2020⁸). <h3>Results</h3> Aim 1: 42.7% of UW participants reported a history of depression, and 78.7% reported SI (figure 1). These values were significantly greater than those for the Global Enroll-HD 2018 dataset (p&lt;0.0001). Alcohol abuse at UW was significantly higher, but drug abuse was not (p&lt;0.0001; p=0.22, respectively) (figure 2). Aim 2: At UW, 86.4% of patients reporting drug abuse had a history of depression, and 100% had a history of SI (figure 3a). Among patients reporting alcohol abuse, 81.6% had a history of depression, and 31.6% had a history of SI (figure 3b). <h3>Conclusion</h3> The UW Enroll site has a high prevalence of depression and SI, especially among those endorsing substance abuse. The strong relationship between reported drug abuse and SI at UW was noteworthy and warrants targeted attention by clinicians. <h3>References</h3> Hasin DS, Sarvet AL, Meyers JL, Saha TD, Ruan WJ, Stohl M, Grant BF. Epidemiology of adult DSM-5 major depressive disorder and its specifiers in the United States. <i>JAMA Psychiatry</i> 2018;<b>75</b>(4):336–346. https://doi.org/10.1001/jamapsychiatry.2017.4602 Hasin DS, Stinson FS, Ogburn E, Grant BF. Prevalence, correlates, disability, and comorbidity of DSM-IV alcohol abuse and dependence in the United States. <i>Archives of General Psychiatry</i> 2007;<b>64</b>(7):830–842. https://doi.org/10.1001/archpsyc.64.7.830 Lim GY, Tam WW, Lu Y, Ho CS, Zhang MW, Ho RC. Prevalence of depression in the community from 30 countries between 1994 and 2014. <i>Scientific Reports</i>, 2018;<b>8</b>(1). https://doi.org/10.1038/s41598-018-21243-x Liu RT, Bettis AH, Burke TA. Characterizing the phenomenology of passive suicidal ideation: a systematic review and meta-analysis of its prevalence, psychiatric comorbidity, correlates, and comparisons with active suicidal ideation. <i>Psychological Medicine</i> 2020;<b>50</b>(3):367–383. https://doi.org/10.1017/s003329171900391x Rocha NP, Tuazon MR, Patino J, Furr Stimming E, Teixeira AL. Clinical correlates of depression and suicidality in huntington disease: an analysis of the enroll-HD observational study. <i>Cognitive and Behavioral Neurology</i> 2022;<b>35</b>(2):85–94. https://doi.org/10.1097/wnn.0000000000000301 Schulden JD, Thomas YF, Compton WM. Substance abuse in the United States: findings from recent epidemiologic studies. <i>Current Psychiatry Reports</i> 2009;<b>11</b>(5):353–359. https://doi.org/10.1007/s11920-009-0053-6 Strashny A, Cairns C, Ashman JJ. <i>Emergency Department Visits With Suicidal Ideation: United States,2016–2020</i>. CDC National Center for Health Statistics.2023, April 12. Symonds AL, Macerollo A, Foy K, Alusi SH, Davies R. Genetic and environmental contributors to neurodegeneration: an exploration of the effects of alcohol on clinical features of huntington’s disease using the enroll-HD global platform. <i>International Journal of Environmental Research and Public Health</i> 2021;<b>18</b>(10):5113. https://doi.org/10.3390/ijerph18105113