Proteogenomic Identification and Analysis of KIF5B as a PrognosticSignature for Hepatocellular Carcinoma
Our findings have suggested KIF5B protein to function as a novel prognostic biomarker in HCC. KIF5B expression has been found to activate the AKT/mTOR pathway and reprogram triglyceride metabolism, leading to HCC development. Targeting KIF5B may be an effective strategy in the clinical treatment of HCC.
Authors
- Yunfei Zhou (ORCID: https://orcid.org/0000-0002-8436-5511)
- Lishuang Qi (ORCID: https://orcid.org/0000-0002-2991-6544)
- Yang Xun (ORCID: https://orcid.org/0000-0002-4244-9805)
- Dabin Liu (ORCID: https://orcid.org/0000-0002-3811-8317)
- Shuyuan Chang
- Yihong Dong
- Yilong Tan (ORCID: https://orcid.org/0009-0009-1780-1190)
- Yu Lei
Institutions
- Harbin Medical University (CN)
- Fourth Affiliated Hospital of Harbin Medical University (CN)
Publication Details
- Journal
- Current Gene Therapy
- Published
- 2024-09-09
- DOI
- https://doi.org/10.2174/0115665232308821240826075513
- Citations
- 25
- Primary Topic
- Cancer, Lipids, and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 7.13