Testing maternal effects of vitamin-D and omega-3 levels on offspring neurodevelopmental traits in the Norwegian Mother, Father and Child Cohort Study
Triangulating across study designs, we did not find evidence for maternal effects. We add to a growing body of evidence that suggests that previous observational associations are likely biased by genetic confounding. Consequently, maternal supplementation is unlikely to influence these offspring neurodevelopmental traits. Notably, genetic predisposition to ADHD and autism was associated with lower DHA and vitamin-D levels respectively, suggesting previous associations might have been due to reverse causation.
Authors
- Kyle Dack (ORCID: https://orcid.org/0000-0003-0319-590X)
- Anne‐Siri Øyen (ORCID: https://orcid.org/0000-0002-1637-992X)
- George Davey Smith (ORCID: https://orcid.org/0000-0002-1407-8314)
- Anita Thapar (ORCID: https://orcid.org/0000-0002-3689-737X)
- Lucy Riglin (ORCID: https://orcid.org/0000-0002-5124-5230)
- Helga Ask (ORCID: https://orcid.org/0000-0003-0149-5319)
- Evie Stergiakouli (ORCID: https://orcid.org/0000-0003-3586-0927)
- Alexandra Havdahl (ORCID: https://orcid.org/0000-0002-9268-0423)
- Robyn E. Wootton (ORCID: https://orcid.org/0000-0003-3961-3202)
- Panagiota Pagoni (ORCID: https://orcid.org/0000-0002-8090-512X)
- Maria Carolina Borges (ORCID: https://orcid.org/0000-0001-7785-4547)
- Paul Madley‐Dowd (ORCID: https://orcid.org/0000-0003-2932-9486)
- Anne Lise Brantsæter (ORCID: https://orcid.org/0000-0001-6315-7134)
- Camilla Stoltenberg (ORCID: https://orcid.org/0000-0002-8747-1985)
- Elizabeth C. Corfield (ORCID: https://orcid.org/0000-0002-0119-157X)
- Hannah Jones (ORCID: https://orcid.org/0000-0002-5883-9605)
- Christine G. Roth
Institutions
- Norwegian Institute of Public Health (NO)
- University of Oslo (NO)
- University Hospitals Bristol NHS Foundation Trust (GB)
- University of Bristol (GB)
- Lovisenberg Diakonale Høgskole (NO)
- NIHR Bristol Biomedical Research Centre (GB)
- University of Bergen (NO)
- Cardiff University (GB)
- Medical Research Council (GB)
Publication Details
- Journal
- Psychological Medicine
- Published
- 2024-09-01
- DOI
- https://doi.org/10.1017/s0033291724001466
- Citations
- 1
- Primary Topic
- Obesity, Physical Activity, Diet
- Type
- article
- Field-Weighted Citation Impact
- 0.54
Funders
- Stiftelsen Kristian Gerhard Jebsen
- Wellcome Trust
- Trond Mohn stiftelse
- National Institute for Health and Care Research
- Department of Health and Social Care
- European Commission
- University of Bristol
- Helse- og Omsorgsdepartementet
- Novo Nordisk
- Helse Vest
- Universitetet i Bergen
- Universitetet i Oslo
- Norges Forskningsråd
- HORIZON EUROPE Framework Programme
- Medical Research Council
- Helse Sør-Øst RHF
- Norwegian Institute of Public Health