Lynch Syndrome-associated Genomic Variants
This study provides new insights into the molecular basis of Lynch syndrome-associated endometrial cancer, emphasizing the overlap in oncogenic pathways with colorectal cancer. The discovery of shared and unique genetic mutations highlights the importance of developing combined treatment strategies and suggests that targeting these specific mutations could improve therapy for patients with Lynch syndrome-associated cancers.
Authors
- Valentin Varlas (ORCID: https://orcid.org/0000-0002-8342-9819)
- Robert Boţea
- Nicolae Suciu (ORCID: https://orcid.org/0000-0001-7436-8463)
- Tiberiu Augustin Georgescu (ORCID: https://orcid.org/0000-0003-2707-1880)
- Madalina Piron-Dumitrascu (ORCID: https://orcid.org/0009-0002-1875-0742)
- Simona Raluca Iacoban (ORCID: https://orcid.org/0009-0008-7125-7758)
- Silviu Cristian Voinea
- Camil Laurentiu Bohiltea
Institutions
- Carol Davila University of Medicine and Pharmacy (RO)
- Institutul National pentru Sanatatea Mamei si Copilului "Alessandrescu-Rusescu" (RO)
- Institutul Oncologic Bucuresti (RO)
Publication Details
- Journal
- Journal of Gastrointestinal and Liver Diseases
- Published
- 2024-09-09
- DOI
- https://doi.org/10.15403/jgld-5856
- Citations
- 2
- Primary Topic
- Genetic factors in colorectal cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.85