Mineralocorticoid Receptor Blocker Prevents Mineralocorticoid Receptor–Mediated Inflammation by Modulating Transcriptional Activity of Mineralocorticoid Receptor–p65–Signal Transducer and Activator of Transcription 3 Complex
Esaxerenone ameliorated postinfarct remodeling in experimental MI through its anti-inflammatory properties exerted by modulating the transcriptional activity of the MR-p65-STAT3 complex. These results suggest that the MR-p65-STAT3 complex can be a novel therapeutic target for treating MI.
Authors
- Yuichiro Arima (ORCID: https://orcid.org/0000-0002-9840-3347)
- Kenichi Tsujita (ORCID: https://orcid.org/0000-0002-4314-259X)
- Kunihiko Matsui (ORCID: https://orcid.org/0000-0002-3750-3440)
- Shinsuke Hanatani (ORCID: https://orcid.org/0000-0001-9627-9373)
- Naoto Kuyama (ORCID: https://orcid.org/0000-0002-5803-5324)
- Taishi Nakamura (ORCID: https://orcid.org/0000-0002-1205-3252)
- Naoya Nakashima (ORCID: https://orcid.org/0000-0001-6298-6141)
- Koichi Kaikita (ORCID: https://orcid.org/0000-0003-2962-8056)
- Masahiro Yamamoto (ORCID: https://orcid.org/0000-0002-6994-040X)
- Satoshi Araki (ORCID: https://orcid.org/0000-0002-8788-3824)
- Eiichiro Yamamoto (ORCID: https://orcid.org/0000-0002-9072-0348)
- Kenichi Matsushita (ORCID: https://orcid.org/0000-0002-6714-8507)
- Nobuhiro Nakanishi
Institutions
- University of Miyazaki (JP)
- Kumamoto University Hospital (JP)
- Kumamoto Medical Center (JP)
- Kumamoto University (JP)
Publication Details
- Journal
- Journal of the American Heart Association
- Published
- 2024-09-09
- DOI
- https://doi.org/10.1161/jaha.123.030941
- Citations
- 5
- Primary Topic
- Hormonal Regulation and Hypertension
- Type
- article
- Field-Weighted Citation Impact
- 1.79
Funders
- Daiichi Sankyo Europe