Association Between Oral Anticoagulant Adherence and Serious Clinical Outcomes in Patients With Atrial Fibrillation: A Long‐Term Retrospective Cohort Study
Even small reductions in OAC adherence in patients with atrial fibrillation were associated with significant increases in risk of stroke, with greater magnitudes for DOAC than VKA. DOAC recipients may be more vulnerable than VKA recipients to increased risk of stroke and death even with small reductions in adherence. The worsening efficacy outcomes associated with decreasing adherence occurred without the benefit of major bleeding reduction.
Authors
- Marc W. Deyell (ORCID: https://orcid.org/0000-0001-8434-7076)
- Shahrzad Salmasi (ORCID: https://orcid.org/0000-0003-1330-3388)
- Mary A. De Vera (ORCID: https://orcid.org/0000-0002-2205-2683)
- Abdollah Safari (ORCID: https://orcid.org/0000-0001-9715-3086)
- Peter Loewen (ORCID: https://orcid.org/0000-0001-7160-6438)
- Adenike Adelakun (ORCID: https://orcid.org/0000-0003-1486-2392)
- Jason G. Andrade (ORCID: https://orcid.org/0000-0002-8493-5123)
- Hamed Helisaz (ORCID: https://orcid.org/0000-0001-7739-1407)
Institutions
- Providence Health Care (CA)
- University of British Columbia (CA)
- University of Tehran (IR)
- Montreal Heart Institute (CA)
- Vancouver General Hospital (CA)
- GlaxoSmithKline (Canada) (CA)
- Providence Health Care Research Institute (CA)
- Centre for Advancing Health Outcomes (CA)
- Université de Montréal (CA)
Publication Details
- Journal
- Journal of the American Heart Association
- Published
- 2024-09-09
- DOI
- https://doi.org/10.1161/jaha.124.035639
- Citations
- 7
- Primary Topic
- Atrial Fibrillation Management and Outcomes
- Type
- article
- Field-Weighted Citation Impact
- 2.81
Funders
- Pfizer
- Servier
- Canadian Institutes of Health Research