Evaluating Thrombolysis Rates and Emergency Department Time Targets in Acute Ischemic Stroke: Need for Personalized Medicine
The ED time targets that significantly influenced IV thrombolysis in our study were the onset-to-ED door time and the time it takes for the ED doctor to assess the AIS patient (door-to-physician time). The IV thrombolysis rate for these patients was 17.83%, lower than expected despite achieving most ED time targets, with the presence of chronic arterial hypertension as a significant predictive patient-related factor for not performing it. Even though our reported hospital's thrombolysis rate is favorable compared to international reports, there is always room for improvement. Based on our study results, it is necessary that new protocols to customized standard protocols and ED time targets for increasing IV thrombolysis rate in patients with AIS in the therapeutic window, focusing more on patient-related factors and type of hospitals, granting personalized medicine its right. Based on our study results, it is necessary that new protocols customize standard protocols and ED time targets for increasing IV thrombolysis rate in patients with AIS in the therapeutic window, focusing more on patient-related factors and type of hospitals, granting personalized medicine its right.
Authors
- Marius Badalica-Petrescu
- Florina Nicoleta Buleu (ORCID: https://orcid.org/0000-0002-9814-9561)
- Anca Tudor (ORCID: https://orcid.org/0000-0001-9630-4727)
- Aida Iancu
- Dumitru Șutoi (ORCID: https://orcid.org/0000-0003-3261-9820)
- Daian Ionel Popa (ORCID: https://orcid.org/0009-0007-1728-3552)
- Carmen J. Williams (ORCID: https://orcid.org/0000-0001-6440-7086)
- Ovidiu Alexandru Mederle (ORCID: https://orcid.org/0000-0002-2242-7764)
- Cosmin Iosif Trebuian (ORCID: https://orcid.org/0009-0001-3217-1889)
- Covasala Constantin Ioan
- Dragoș Forțofoiu (ORCID: https://orcid.org/0009-0002-4143-844X)
- Ion Petre (ORCID: https://orcid.org/0000-0001-9168-269X)
Institutions
- Clinical Emergency Hospital Bucharest (RO)
- University of Medicine and Pharmacy of Craiova (RO)
- Arad County Clinical Hospital (RO)
- Victor Babeș University of Medicine and Pharmacy Timișoara (RO)
Publication Details
- Journal
- Journal of Personalized Medicine
- Published
- 2024-09-09
- DOI
- https://doi.org/10.3390/jpm14090955
- Citations
- 2
- Primary Topic
- Acute Ischemic Stroke Management
- Type
- article
- Field-Weighted Citation Impact
- 0.77