Disruptions in antigen processing and presentation machinery on sarcoma
Sarcomas exhibit a high degree of defects in APM components, with differences among histotypes and tumoral areas. The most commonly altered APM components were HLA Class I subunit β2-microglobulin, HLA Class I subunit α (HC10), and MHC I transporting unit TAP2. The loss of APM components was prognostic of DM and OS and clinically relevant for LMS and DDLPS. This study explores sarcoma molecular mechanisms, enriching personalized therapeutic approaches.
Authors
- Ömer Mintemur (ORCID: https://orcid.org/0000-0003-3055-9094)
- Ilaria Santori (ORCID: https://orcid.org/0009-0000-2063-3399)
- Luigi Terracciano (ORCID: https://orcid.org/0000-0002-9393-9660)
- Vittorio Quagliuolo (ORCID: https://orcid.org/0000-0002-6102-0000)
- Ferdinando Cananzi (ORCID: https://orcid.org/0000-0002-8227-3373)
- Alice Laffi (ORCID: https://orcid.org/0000-0001-7458-3366)
- Fabio Grizzi (ORCID: https://orcid.org/0000-0003-0925-742X)
- Alexia Bertuzzi (ORCID: https://orcid.org/0000-0002-8933-9929)
- Pierina Navarria (ORCID: https://orcid.org/0000-0002-6913-1442)
- Federico Sicoli (ORCID: https://orcid.org/0000-0002-6845-643X)
- Piergiuseppe Colombo (ORCID: https://orcid.org/0000-0002-6161-6138)
- Maurizio D’Incalci (ORCID: https://orcid.org/0000-0001-8784-1360)
- Salvatore Lorenzo Renne (ORCID: https://orcid.org/0000-0002-0186-1318)
- Laura Samà (ORCID: https://orcid.org/0000-0001-9036-7444)
- Fabio Pasqualini (ORCID: https://orcid.org/0000-0003-4852-3794)
- Arturo Bonometti (ORCID: https://orcid.org/0000-0003-3258-0727)
- Alessandra Bressan (ORCID: https://orcid.org/0000-0002-6814-7733)
- Marta Scorsetti (ORCID: https://orcid.org/0000-0003-0320-559X)
- Laura Ruspi (ORCID: https://orcid.org/0000-0002-1282-4352)
- Sonia Kumar
- Vittoria D’Amato
Institutions
- Humanitas University (IT)
- IRCCS Humanitas Research Hospital (IT)
Publication Details
- Journal
- Cancer Immunology Immunotherapy
- Published
- 2024-09-09
- DOI
- https://doi.org/10.1007/s00262-024-03822-2
- Citations
- 2
- Primary Topic
- CAR-T cell therapy research
- Type
- article
- Field-Weighted Citation Impact
- 0.57
Funders
- Ministero della Salute