CEBPB dampens the cuproptosis sensitivity of colorectal cancer cells by facilitating the PI3K/AKT/mTOR signaling pathway
This work demonstrated that CEBPB can activate the PI3K/AKT/mTOR signaling pathway, thereby decreasing the sensitivity of CRC to cuproptosis. These data suggested that targeting CEBPB or the PI3K/AKT/mTOR pathway may enhance the sensitivity of CRC patients to cuproptosis, providing a combined therapeutic strategy for cuproptosis-induced therapy.
Authors
- Xiaodong Han (ORCID: https://orcid.org/0000-0003-4512-3699)
- Tianchen Huang
- Lei Li (ORCID: https://orcid.org/0009-0004-7611-4829)
- Kan Li (ORCID: https://orcid.org/0000-0002-5762-7440)
- Yong Zhang (ORCID: https://orcid.org/0000-0002-1303-0458)
- Yachao Wu
- Zhi‐Peng Guo (ORCID: https://orcid.org/0000-0001-8193-6086)
- Weijie Wang
- Yanshan Xin
Institutions
- Anyang Tumor Hospital (CN)
Publication Details
- Journal
- Saudi Journal of Gastroenterology
- Published
- 2024-09-09
- DOI
- https://doi.org/10.4103/sjg.sjg_169_24
- Citations
- 14
- Primary Topic
- Cancer, Lipids, and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 3.99