Toxicity profiles of immune checkpoint inhibitors in nervous system cancer: a comprehensive disproportionality analysis using FDA adverse event reporting system
This study helps to characterize irAEs in NSC patients treated with ICIs. We combined GEO database analysis to explore the potential molecular mechanisms of irAEs. The results of this study provide a basis for improving the toxic effects of ICIs in NSC patients.
Authors
- Zenghong Lu (ORCID: https://orcid.org/0000-0003-1565-9708)
- Fangjun Zhong
- Zhengang Qiu
- Changyi Liu
- Yu Zhang (ORCID: https://orcid.org/0000-0003-1025-906X)
- Hui Zhao (ORCID: https://orcid.org/0000-0003-1614-1994)
- Rongrong Liu
- Lingshuai Zeng
- Longqiu Wu
- Huaqiu Shi
- Jing Wang (ORCID: https://orcid.org/0000-0001-7431-8925)
Institutions
- Jinggangshan University (CN)
- Ganzhou People's Hospital (CN)
- First Affiliated Hospital of Gannan Medical University (CN)
Publication Details
- Journal
- Clinical and Experimental Medicine
- Published
- 2024-09-09
- DOI
- https://doi.org/10.1007/s10238-024-01403-2
- Primary Topic
- Cancer Immunotherapy and Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Jiangxi Province
- Education Department of Jiangxi Province
- Chinese Society of Clinical Oncology
- Gannan Medical University