Spatial regulation of NMN supplementation on brain lipid metabolism upon subacute and sub-chronic PM exposure in C57BL/6 mice
This study demonstrates that NMN intervention effectively reduces neuroinflammation in the hippocampus and hypothalamus after PM exposure by modulating spatial lipid metabolism. Strategies targeting the improvement of lipid homeostasis may provide significant protection against brain injury associated with air pollutant exposure.
Authors
- Hui Peng (ORCID: https://orcid.org/0000-0002-0220-3616)
- Xiao‐Wen Zeng (ORCID: https://orcid.org/0000-0003-3918-1841)
- Guang‐Hui Dong (ORCID: https://orcid.org/0000-0002-2578-3369)
- Lizhu Ye
- Daochuan Li
- Chen Shen (ORCID: https://orcid.org/0000-0003-3535-8494)
- Wen Chen (ORCID: https://orcid.org/0000-0001-6075-3192)
- Chunyang Liao (ORCID: https://orcid.org/0000-0003-2846-6614)
- Fang Li (ORCID: https://orcid.org/0000-0001-9180-3615)
- Rong Zhang (ORCID: https://orcid.org/0000-0001-9608-2650)
- Rui Zhang (ORCID: https://orcid.org/0000-0001-9000-5021)
- Qian Luo (ORCID: https://orcid.org/0009-0002-0768-5068)
- Yue Jiang (ORCID: https://orcid.org/0000-0003-4965-7276)
- Liping Chen (ORCID: https://orcid.org/0009-0003-4224-1363)
- Wei Xu
- Haiyang Zhang (ORCID: https://orcid.org/0000-0001-7951-0502)
Institutions
- Hebei Medical University (CN)
- Sun Yat-sen University (CN)
- Chinese Academy of Sciences (CN)
- Research Center for Eco-Environmental Sciences (CN)
- Shenzhen Institutes of Advanced Technology (CN)
Publication Details
- Journal
- Particle and Fibre Toxicology
- Published
- 2024-09-09
- DOI
- https://doi.org/10.1186/s12989-024-00597-3
- Citations
- 5
- Primary Topic
- Biochemical effects in animals
- Type
- article
- Field-Weighted Citation Impact
- 1.63
Funders
- National Natural Science Foundation of China
- Basic and Applied Basic Research Foundation of Guangdong Province