EGFR and EGFRvIII coopt host defense pathways promoting progression in glioblastoma
Together, our findings show that EGFR and EGFRvIII cooperate to drive tumor progression through ROCK2 and downstream WNT-β-catenin/TLR2 signaling pathways.
Authors
- Joanna J. Phillips (ORCID: https://orcid.org/0000-0002-3789-8120)
- Hiroyuki Yoda (ORCID: https://orcid.org/0000-0002-5528-8940)
- Nevan J. Krogan (ORCID: https://orcid.org/0000-0003-4902-337X)
- David Jimenez‐Morales (ORCID: https://orcid.org/0000-0003-4356-6461)
- William A. Weiss (ORCID: https://orcid.org/0000-0003-2230-9132)
- Erica Stevenson (ORCID: https://orcid.org/0000-0001-7853-1854)
- Ethan Lee (ORCID: https://orcid.org/0000-0001-8405-6156)
- Danielle L. Swaney (ORCID: https://orcid.org/0000-0001-6119-6084)
- Megumi J. Barata
- Qi-Wen Fan
- Linyu Wang (ORCID: https://orcid.org/0000-0002-5455-3503)
- Zhenyi An
Institutions
- QB3 (US)
- Gladstone Institutes (US)
- University of California, San Francisco (US)
- Vanderbilt University (US)
- Quantitative BioSciences (US)
- Neurological Surgery (US)
- UCSF Helen Diller Family Comprehensive Cancer Center (US)
Publication Details
- Journal
- Neuro-Oncology
- Published
- 2024-09-09
- DOI
- https://doi.org/10.1093/neuonc/noae182
- Citations
- 8
- Primary Topic
- Cancer-related molecular mechanisms research
- Type
- article
- Field-Weighted Citation Impact
- 2.28
Funders
- Sandler Foundation
- Cancer Research UK
- National Institutes of Health
- University of California, San Francisco