Structural reconstruction of mouse acute aortic dissection by intravenously administered human Muse cells without immunosuppression
Intravenously administered Muse cells reconstruct the dissected aorta and improve mortality and diameter enlargement rates. Moreover, small doses of purified Muse cells are more effective than large doses of MSCs. HLA-G is suggested to contribute to the successful survival and homing of Muse cells.
Authors
- Yasuhiro Horibata (ORCID: https://orcid.org/0009-0004-3384-4354)
- Yoshihiro Kushida (ORCID: https://orcid.org/0000-0002-5840-5292)
- Yoshikatsu Saiki (ORCID: https://orcid.org/0000-0003-0959-7133)
- Shohei Wakao (ORCID: https://orcid.org/0000-0003-1888-939X)
- Mari Dezawa (ORCID: https://orcid.org/0000-0001-9978-6178)
- Hiroyuki Sugimoto (ORCID: https://orcid.org/0000-0003-4967-392X)
- Makoto Takahashi (ORCID: https://orcid.org/0000-0001-6073-7985)
- Yasumasa Kuroda
Institutions
- Tohoku University (JP)
- Dokkyo Medical University (JP)
Publication Details
- Journal
- Communications Medicine
- Published
- 2024-09-09
- DOI
- https://doi.org/10.1038/s43856-024-00597-6
- Citations
- 6
- Primary Topic
- Aortic Disease and Treatment Approaches
- Type
- article
- Field-Weighted Citation Impact
- 2.51
Funders
- Japan Society for the Promotion of Science