A novel mouse model recapitulates the effects of rs2254524 variant in the lanosterol synthase gene on salt sensitivity and organ damage
The novel Lss mouse model resembles the salt-sensitive HT phenotype observed in hypertensive patients and provides a good model of salt-sensitive HT and HT-mediated organ damage.
Authors
- Chiara Lanzani (ORCID: https://orcid.org/0000-0002-5332-4012)
- Francesca Sanvito (ORCID: https://orcid.org/0000-0002-4046-8420)
- Marco Simonini (ORCID: https://orcid.org/0000-0003-0664-4600)
- Elisabetta Messaggio (ORCID: https://orcid.org/0000-0002-7308-4562)
- Sipontina Faienza (ORCID: https://orcid.org/0000-0002-1773-5359)
- Lorena Citterio (ORCID: https://orcid.org/0000-0001-6455-2291)
- Luca Rampoldi (ORCID: https://orcid.org/0000-0002-0544-7042)
- Barbara Canciani (ORCID: https://orcid.org/0000-0003-1942-1174)
- Paolo Manunta (ORCID: https://orcid.org/0000-0003-3976-9696)
- Laura Zagato (ORCID: https://orcid.org/0000-0002-0441-2120)
- Davor Pavlović (ORCID: https://orcid.org/0000-0002-3171-3551)
Institutions
- Vita-Salute San Raffaele University (IT)
- Istituto Clinico Sant'Ambrogio (IT)
- Institute of Experimental Endocrinology of the Slovak Academy of Sciences (SK)
- IRCCS Ospedale San Raffaele (IT)
- University of Birmingham (GB)
Publication Details
- Journal
- Journal of Hypertension
- Published
- 2024-08-19
- DOI
- https://doi.org/10.1097/hjh.0000000000003843
- Primary Topic
- Hormonal Regulation and Hypertension
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Ministero della Salute