Antiangiogenic Tyrosine Kinase Inhibitors have Differential Efficacy in Clear Cell Renal Cell Carcinoma in Bone
TKIs showed different efficacy in synchronous bone and lung metastases and did not eradicate tumors as single agents but induced extensive reprogramming of the BM microenvironment. This resulted in a significant decrease in neoangiogenic blood vessels, bone remodeling, and immune cell infiltration (including CD8 T cells) with altered spatial distribution.
Authors
- Jared K. Burks (ORCID: https://orcid.org/0000-0002-6173-9074)
- Matthew T. Campbell (ORCID: https://orcid.org/0000-0003-1915-4491)
- Christopher Alvarez‐Breckenridge (ORCID: https://orcid.org/0000-0001-5997-6532)
- Sergio Barrios (ORCID: https://orcid.org/0000-0003-0364-2466)
- Wenjiao Li (ORCID: https://orcid.org/0000-0003-1308-8489)
- Stefan Maksimovic (ORCID: https://orcid.org/0000-0001-7373-082X)
- Emanuela Gentile (ORCID: https://orcid.org/0000-0002-0332-2385)
- Eleonora Dondossola (ORCID: https://orcid.org/0000-0001-6916-5418)
- Javier A. Gomez (ORCID: https://orcid.org/0000-0002-6579-744X)
- Jianjun Gao (ORCID: https://orcid.org/0000-0001-6138-4472)
- Jianfeng Chen (ORCID: https://orcid.org/0000-0003-3750-1207)
- Akshay Basi
- Pedro I. Pesquera (ORCID: https://orcid.org/0009-0007-6318-1290)
- Nina C. Boscolo
- Mohammad Jad Moussa (ORCID: https://orcid.org/0009-0000-7960-8614)
- Ludovica La Posta
Institutions
- The University of Texas MD Anderson Cancer Center (US)
- Rice University (US)
Publication Details
- Journal
- Cancer Research Communications
- Published
- 2024-09-09
- DOI
- https://doi.org/10.1158/2767-9764.crc-24-0304
- Citations
- 3
- Primary Topic
- Renal cell carcinoma treatment
- Type
- article
- Field-Weighted Citation Impact
- 1.26