Cognitive phenotypes: Unraveling the heterogeneity in cognitive dysfunction among patients with primary brain tumors receiving radiotherapy
We identified 3 distinct cognitive phenotypes in patients with primary brain tumors receiving RT, each associated with unique demographic and clinical (eg, IDH mutational status) profiles, with mood symptoms associated with late cognitive decline. This patient-centered approach enhances our understanding of clinical profiles associated with cognitive dysfunction and treatment-related neurotoxicity.
Authors
- Mia Salans (ORCID: https://orcid.org/0000-0002-5195-5590)
- Lily Kamalyan (ORCID: https://orcid.org/0000-0002-3099-0549)
- Austin Hopper (ORCID: https://orcid.org/0000-0003-2554-1535)
- Jona A. Hattangadi‐Gluth (ORCID: https://orcid.org/0000-0001-8222-606X)
- Anny Reyes (ORCID: https://orcid.org/0000-0003-0625-6990)
- Molly Wilkinson (ORCID: https://orcid.org/0000-0001-6494-2759)
- Divya Prabhakaran (ORCID: https://orcid.org/0000-0002-0152-7547)
- Jiwandeep S. Kohli (ORCID: https://orcid.org/0000-0002-1704-155X)
- Jonathan L. Helm (ORCID: https://orcid.org/0000-0001-8580-980X)
- Soumya Unnikrishnan (ORCID: https://orcid.org/0009-0009-0325-4122)
- Carrie R. McDonald (ORCID: https://orcid.org/0000-0002-0721-5640)
- Roshan Karunamuni
- Alena Stasenko (ORCID: https://orcid.org/0000-0001-9446-9018)
Institutions
- Emory University (US)
- University of California, San Francisco (US)
- San Diego State University (US)
- University of California San Diego (US)
Publication Details
- Journal
- Neuro-Oncology
- Published
- 2024-09-09
- DOI
- https://doi.org/10.1093/neuonc/noae183
- Citations
- 6
- Primary Topic
- Cancer-related cognitive impairment studies
- Type
- article
- Field-Weighted Citation Impact
- 2.51
Funders
- National Institutes of Health