Changes in the pharyngeal and nasal microbiota in pediatric patients with adenotonsillar hypertrophy

Adenotonsillar hypertrophy (AH) is considered the main cause of breathing disorders during sleep in children. AH patients, after significant morbidity and often multiple courses of antibiotics, often proceed to tonsillectomy and/or adenoidectomy. Given the potential risks associated with these procedures, there is a growing interest in the use of nonsurgical adjuvant therapies, such as probiotics, that could potentially reduce their need for surgical intervention. In this study, we investigated the pharyngeal and nasal microbiota in patients with AH compared with healthy children. Furthermore, we tested the effects of probiotic spray administration on both disease symptoms and microbiota profiles, to evaluate the possible use of this microbial therapy as an adjuvant for AH patients.

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Publication Details

Journal
Microbiology Spectrum
Published
2024-09-09
DOI
https://doi.org/10.1128/spectrum.00728-24
Citations
6
Primary Topic
Obstructive Sleep Apnea Research
Type
article
Field-Weighted Citation Impact
1.96

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article

Changes in the pharyngeal and nasal microbiota in pediatric patients with adenotonsillar hypertrophy

Federica D. Del Chierico, Ersilia Fiscarelli, Alessandra Russo, Antonia Piazzesi et al.
6 citations
Microbiology Spectrum
Obstructive Sleep Apnea Research
1.96
article

Changes in the pharyngeal and nasal microbiota in pediatric patients with adenotonsillar hypertrophy

Federica D. Del Chierico, Ersilia Fiscarelli, Alessandra Russo, Antonia Piazzesi, Sara Santarsiero, Maria Vittoria Ristori, Giovanni Carlo De Vincentis, Fabrizio Del Bianco, Gabriele Macari, Valerio Damiani, Lorenza Putignani, Ilaria Pirona, Luigi Mercuri, Nicoletta Citerà, Valeria Antenucci
article en
6 citations

Abstract

Adenotonsillar hypertrophy (AH) is considered the main cause of breathing disorders during sleep in children. AH patients, after significant morbidity and often multiple courses of antibiotics, often proceed to tonsillectomy and/or adenoidectomy. Given the potential risks associated with these procedures, there is a growing interest in the use of nonsurgical adjuvant therapies, such as probiotics, that could potentially reduce their need for surgical intervention. In this study, we investigated the pharyngeal and nasal microbiota in patients with AH compared with healthy children. Furthermore, we tested the effects of probiotic spray administration on both disease symptoms and microbiota profiles, to evaluate the possible use of this microbial therapy as an adjuvant for AH patients.

Microbiology SpectrumVol. 12(10)
Bambino Gesù Children's Hospital (IT), Istituti di Ricovero e Cura a Carattere Scientifico (IT)
Ministero della Salute
Openalex Percentile: Top 13%
Obstructive Sleep Apnea Research
1.96
DOIOpen Access PDFOpenAlex
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Changes in the pharyngeal and nasal microbiota in pediatric patients with adenotonsillar hypertrophy — Federica D. Del Chierico, Ersilia Fiscarelli, et al. · Microbiology Spectrum (2024) | TGRS Research Map | TGRS