Diverse BCR usage and T cell activation induced by different COVID-19 sequential vaccinations

Using the same laboratory test to avoid unnecessary interference due to cohort ethnicity, and experimental and statistical errors, we have compared the T/B cell immune response in the same cohort sequential vaccinated by different types of COVID-19 vaccine. We found that different sequential vaccinations can induce different dominant BCR usage with no significant neutralizing titers and RBD<sup>+</sup> B-cell phenotype. Recombinant protein vaccine can induce higher numbers of regulatory T cells, circulating TFH (CTFH)1, CTFH17, and CTFH-CM, and lower SMNE<sup>+</sup> T-cell proliferative capacity than the other two groups, whereas I-I-A showed higher proportion and number of virus-specific CD4<sup>+</sup> T cells than I-I-R. Overall, our study provides a deep insight about the source of differences in immune protection of different types of COVID-19 vaccines, which further improves our understanding of the mechanisms underlying the immune response to SARS-CoV-2.

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Publication Details

Journal
mBio
Published
2024-09-09
DOI
https://doi.org/10.1128/mbio.01429-24
Citations
1
Primary Topic
SARS-CoV-2 and COVID-19 Research
Type
article
Field-Weighted Citation Impact
0.39

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article

Diverse BCR usage and T cell activation induced by different COVID-19 sequential vaccinations

Kaiwen Zhou, Jinpeng Cao, Zhongfang Wang, Kaiyi Li et al.
1 citations
mBio
SARS-CoV-2 and COVID-19 Research
0.39
article

Diverse BCR usage and T cell activation induced by different COVID-19 sequential vaccinations

Kaiwen Zhou, Jinpeng Cao, Zhongfang Wang, Kaiyi Li, Xinyue Liang, Xiaobing Zhai, Xinyue Mei, Jing-Lu Yang, Yuan Wang, Weidong Li, Junxiang Wang, Rui Wei, Zhengfang Lin, Deyi Huang
article en
1 citations

Abstract

Using the same laboratory test to avoid unnecessary interference due to cohort ethnicity, and experimental and statistical errors, we have compared the T/B cell immune response in the same cohort sequential vaccinated by different types of COVID-19 vaccine. We found that different sequential vaccinations can induce different dominant BCR usage with no significant neutralizing titers and RBD<sup>+</sup> B-cell phenotype. Recombinant protein vaccine can induce higher numbers of regulatory T cells, circulating TFH (CTFH)1, CTFH17, and CTFH-CM, and lower SMNE<sup>+</sup> T-cell proliferative capacity than the other two groups, whereas I-I-A showed higher proportion and number of virus-specific CD4<sup>+</sup> T cells than I-I-R. Overall, our study provides a deep insight about the source of differences in immune protection of different types of COVID-19 vaccines, which further improves our understanding of the mechanisms underlying the immune response to SARS-CoV-2.

mBioVol. 15(10)
West China Medical Center of Sichuan University (CN), First Affiliated Hospital of Guangzhou Medical University (CN), Guangzhou Regenerative Medicine and Health Guangdong Laboratory (CN), Dongguan People’s Hospital (CN), State Key Laboratory of Respiratory Disease (CN), Guangzhou Medical University (CN)
National Natural Science Foundation of China, National Key Research and Development Program of China
Good health and well-being
Openalex Percentile: Top 37%
SARS-CoV-2 and COVID-19 Research
0.39
DOIOpen Access PDFOpenAlex
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