[131I]6ß-Iodomethyl-19-norcholesterol SPECT/CT for the Lateralization of Mineralocorticoid Overproduction in Primary Aldosteronism

[<sup>131</sup>I]6ß-iodomethyl-19-norcholesterol SPECT/CT with a count-based image interpretation and side-ratio calculation may be an equipollent non-invasive substitute for adrenal venous sampling in the lateralization of mineralocorticoid overproduction. It reliably identifies unilateral disease and facilitates patients' selection for surgical intervention. If confirmed by others, this functional imaging may replace AVS when lateralization is required for management decisions in primary aldosteronism.

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Publication Details

Journal
Diagnostics
Published
2024-09-09
DOI
https://doi.org/10.3390/diagnostics14171997
Primary Topic
Hormonal Regulation and Hypertension
Type
article
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article

[131I]6ß-Iodomethyl-19-norcholesterol SPECT/CT for the Lateralization of Mineralocorticoid Overproduction in Primary Aldosteronism

Lívia Sira, E. Nagy, Sándor Barna, Zsigmond Czine et al.
Diagnostics
Hormonal Regulation and Hypertension
article

[131I]6ß-Iodomethyl-19-norcholesterol SPECT/CT for the Lateralization of Mineralocorticoid Overproduction in Primary Aldosteronism

Lívia Sira, E. Nagy, Sándor Barna, Zsigmond Czine, József Varga, Zita Képes, Harjit Pal Bhattoa, Miklós Bodor, Endre Vezekenyi Nagy, László Tóth, Lilla Szoboszlay, Ildikó Garai
article en

Abstract

[<sup>131</sup>I]6ß-iodomethyl-19-norcholesterol SPECT/CT with a count-based image interpretation and side-ratio calculation may be an equipollent non-invasive substitute for adrenal venous sampling in the lateralization of mineralocorticoid overproduction. It reliably identifies unilateral disease and facilitates patients' selection for surgical intervention. If confirmed by others, this functional imaging may replace AVS when lateralization is required for management decisions in primary aldosteronism.

DiagnosticsVol. 14(17)
University of Debrecen (HU), Jósa András Múzeum (HU)
Good health and well-being
Openalex Percentile: Top 77%
Hormonal Regulation and Hypertension
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