Effects of exogenous deoxyribonuclease I in collagen antibody-induced arthritis
Our results suggest that exogenous DNase I does not prevent the development of CAIA in mice. Whether this is true for other animal models of arthritis or clinical RA requires further research. EcDNA does not seem to be involved in the pathogenesis of CAIA. Additional studies are also needed to elucidate the role of ecDNA in the development of RA, focusing especially on its origin and inhibition of ecDNA release.
Authors
- Richard Hokša
- Veronika Borbélyová (ORCID: https://orcid.org/0000-0001-7014-9626)
- Jakub Janko (ORCID: https://orcid.org/0000-0002-3256-6960)
- Michal Pastorek
- Norbert Moravanský
- Kristína Macáková (ORCID: https://orcid.org/0009-0003-1593-5175)
- Peter Celec (ORCID: https://orcid.org/0000-0001-5883-3580)
- Barbora Vlková (ORCID: https://orcid.org/0000-0003-3907-5432)
- Emὄke Šteňová (ORCID: https://orcid.org/0000-0001-6595-2959)
- Mária Tekeľová
Institutions
- University Hospital Bratislava (SK)
- Public Health Authority of the Slovak Republic (SK)
- Institute of Forensic Science (CN)
- Comenius University Bratislava (SK)
Publication Details
- Journal
- Journal of Inflammation
- Published
- 2024-09-09
- DOI
- https://doi.org/10.1186/s12950-024-00403-z
- Citations
- 5
- Primary Topic
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 1.20
Funders
- Agentúra na Podporu Výskumu a Vývoja