EP11.14: Incidence of intrahepatic cholestasis in pregnancy and assessment of maternal and fetal prognosis

To provide current data on the management and treatment of intrahepatic cholestasis of pregnancy in our institution, to further improve the maternal and perinatal prognosis of these patients. The study is a retrospective-analytical type and the data obtained are from January 2014 to March 2023. The data are taken from the files placed in the statistics department of GOUH “Koço Gliozheni” in Tirana, Albania. 80 patients were included in the study. For each patient diagnosed, 4 patients were taken as a control group. Fetomaternal outcomes were evaluated and compared. Maternal age, BMI, parity do not affect cholestasis. Bile acids, AST, ALT, bilirubinemia are increased and begin to normalise 24 hours after birth. The average weight of babies is 3,069g, the weight of babies of mothers with cholestasis is smaller. 89% of births were SC and 11% vaginal births, 58.3% were birth planning as indication, 16.7% emergency and 25% had birth activity. The cause of REA hospitalization of babies in 17.9% is prolonged adaptation, 21.5% is respiratory distress, hyperbilirubinemia in 37.2% and meconium aspiration in 19.6% of cases. Babies born to mothers with intrahepatic cholestasis have more likely to have APGAR min 5 below 7. (OD ratio = 8.065 df = 1, p = 0.004) and to have hospitalization in reanimation department due to preterm birth (OD ratio = 50.820, df = 1, p < 0.001). Increased mother bilirubinemia have a significant relationship with neonatal exposure (OD ratio = 7.327, df = 3, p = 0.001). Meconium was observed in 38.8% of cases (OD = 50.2, df = 1, p = 0.042), while hyperbilirubinemia in 21.5% of cases (OD = 61.1 df = 1 p = 0.001). 89.7% of cases had cessation of clinical symptoms as early as the first week after birth. Intrahepatic cholestasis is a pathology that itself does not indicate early termination of pregnancy or delivery with maternal Caesarean section planning but indicates careful follow-up of clinical and laboratory signs and planning the time and manner of delivery comparing maternal to fetal prognosis.