EP17.15: Evaluation of clinical and biophysical markers as a screening test for late‐onset pre‐eclampsia between 35 and 38 weeks of gestation

To evaluate the performance of screening for pre-eclampsia (PE) at 35-38 weeks' gestation using maternal and biophysical factors. This prospective observational study included singleton pregnancies undergoing an ultrasound scan at 35+0 to 37+6 weeks as part of routine care. The dependent variable was term PE, and the independent variables were clinical characteristics, uterine artery Doppler mean pulsatility index (UtA-PI), and mean arterial pressure (MAP). Univariate and multivariate analyses were performed to determine a predictor model for PE. The study included 949 pregnancies, with 46 (4.8%) developing PE. Pregnancies with late-onset PE showed increased maternal age, body mass index (BMI), MAP, and UtA-PI. Using maternal factors alone, the detection rate for late PE was around 22% at a 10% false positive rate, which was not improved by adding UtA-PI. However, the combined model's detection rate increased to around 60% with the addition of MAP. Screening with a combination of maternal factors (age and BMI) and MAP at 35-38 weeks' gestation could identify a high proportion of pregnancies at risk for late-onset PE.