EP09.14: Neurodevelopmental outcomes in infants with left heart obstructions and transposition of the great arteries

Children with congenital heart disease (CHD) are at risk of neurodevelopmental disorders, decreased functional status and quality of life outcomes. Risk factors are multiple and often little understood yet. Data about hypoplastic left heart syndrome (HLHS) and transposition of the great arteries (TGA) children have been already published but few data are available about children with non-HLHS left heart obstructions such as aortic coarctation (CoAo) simple or associated to other lesions. We studied neurodevelopmental outcomes in CoAo and TGA patients compared with controls. Children with CoAo (simple, complex and shone syndrome) (n = 39), children with TGA (n = 54) and healthy controls (n = 24) aged 12 months were included. To avoid bias in the interpretation of results, only children with isolated congenital heart disease without associated genetic syndromes were considered. Children with TGA presented significantly lower mean scores on the cognitive (M = 98.89 ± 7.99; p < .001), language (M = 95.92 ± 7.05; p < .001) and motor scales (M = 86.34 ± 10.26; p < .001) compare to children with CoAo (Cognitive M = 103.97 ± 7.96; language M = 100.18 ± 7.12; Motor M = 94.21 ± 6.91) and healthy controls (Cognitive M = 107.04 ± 7.34; language M = 105.18 ± 6.44; Motor M = 97.65 ± 8.93). However all group had mean scores within the normal range. Children with CoAo did not differ in their development from healthy children. Within the group of children with CoAo, no significant differences were found according to disease severity (simple CoAo; complex CoAo; Shone syndrome). Two children with TGA showed developmental delay (Cognitive<85); 17 children with TGA and 3 children with CoAo showed delay in the area of motor skills. Our results show that at 1 year infants with CoAo have neurodevelopmental scores comparable to controls while TGA patients are a significantly lower level, although within the normal ranges. However longer follow-up is needed.