EP25.10: Fertility in patients treated with microwave ablation for uterine fibroids

To study pregnancy, its prognosis, and factors affecting after uterine fibroid (UF) treatment by MWA. The patients with symptomatic UFs desired to preserve fertility were treatment by MWA with endometrial protection. The history of pregnancy and parity, spontaneous or induced abortions, spontaneous deliveries, Caesarean sections, assisted reproduction were recorded. The time and mode of conception, pregnancy outcome, and perinatal adverse events were follow up. Of the 81, 45 patients achieved 50 successful pregnancies, of which 39 pregnancies (84%) conceived naturally, and three conceived twice. Six patients underwent assisted reproductive technology (ART) and achieved eight pregnancies (16%). Of the 50 pregnancies, 11 ended in a spontaneous abortion, and nine in an elective abortion. Among the 30 pregnancies of the remaining 29 patients, one infant did not survive due to placental abruption at gestation week 26, one was lost after 13 weeks of pregnancy. The remaining 24 patients successfully delivered 25 offspring, six by natural vaginal delivery (24%; 6/25) and 19 by Caesarean section (76%; 19/25). The safe birth rate was 100% (25/25). The median time from MWA treatment to pregnancy was 18 (1–60) months, and the pregnancy rate was 55.56% (45/81). Among the 81 patients, 18 were diagnosed with primary infertility before the MWA, of whom four (22.22%) successfully became pregnant after the MWA and two successfully delivered healthy babies by a Caesarean section. The other two pregnancies ended due to spontaneous abortions. The live birth rate among the 25 successful deliveries was 100%. By the end of the follow-up, the children had an average age of 45.24 ± 32.21 months and were all in good health. No complications were observed except for one who had placental abruption at gestation week 26. The patient's age, history of spontaneous abortion, and fibroid type were significant predictors of pregnancy after treatment (P < 0.0). MWA could be used as an alternative safe, minimally invasive treatment for patients desired to preserve fertility.