EP09.44: Prenatal diagnosis and prenatal outcome of single ventricle cardiac defect in Vietnam, a developing country

To describe the perinatal outcome after prenatal diagnosis of single ventricle cardiac defect in Vietnam, a developing country. We reviewed all pregnant women with prenatal diagnosis of single ventricle cardiac defect at Vietnamese National Hospital of Gynecology and Obstetrics between January 2017 and December 2021. Patients without follow-up after prenatal diagnosis, diagnosed with heterotaxy syndrome or atrioventricular canal defect were excluded. Live births were followed and assessed up to 12 months of age. Among 417 cases of congenital single ventricle cardiac defect (290 dominant right ventricle (RV), 127 dominant left ventricle (LV)), there were 337 (81%) elective terminations of pregnancy, 3 (0.7%) cases of spontaneous intrauterine fetal demise and 76 (18%) live births. Within 76 liveborns, 28/35 (80%) dominant LV and 32/41 (78%) dominant RV were treated according to familial desire, the rest were under palliative care. Among the treated group, after the first month of life, there was no difference in survival rate between dominant LV (86%) and dominant RV (69%) (p = 0.12). At 6 months and 12 months of age, the survival rate of dominant LV was significantly higher than that of dominant RV (75% versus 46%, p = 0.007, and 75% versus 43%, p = 0.004 respectively). In Vietnam, the rate of TOP due to prenatal diagnosis of single ventricle cardiac defect was high. Among treated liveborns, although there was no difference in survival rate between the dominant LV and dominant RV group after the first month of age, the dominant LV group had a significantly better survival prognosis than that of dominant RV at 6 months and 12 months. These findings were crucial during prenatal counselling for pregnant women and their families.