EP05.22: Fetal corpus callosum pathologies: magnetic resonance imaging role and outcome

The study explores corpus callosum malformation (CCM) using comprehensive brain Magnetic Resonance Imaging (MRI) assessments to uncover associated anomalies and understand postnatal outcomes. During a 7-year period, all cases of CCM diagnosed via fetal MRI were retrospectively studied. Neurodevelopmental outcomes were assessed through postnatal interviews. The study included 59 participants with CCM. In 74.6% of CCM cases, additional intracranial abnormalities were observed, including cortical malformation (45.8%), periventricular nodular heterotopia (25.4%), parenchymal signal abnormality (25.4%), and sulcation delay (16.9%). Additionally, 16.9% of CCM cases were associated with non-neurological anomalies, such as craniofacial malformations (8.5%) and urinary abnormalities (5.1%). A significant association was observed between the coexistence of cortical malformation and poor prognosis (p = 0. 012). Complex CCM cases showed a trend towards poorer outcomes than isolated cases. Among living cases, 30.4% of complex CCM had neurodevelopmental delay and/or seizures, compared to 14.3% of isolated CCM. The broad spectrum of neurological and non-neurological anomalies linked to CCM, along with their clinical outcomes, underscores the pivotal role of MRI in prenatal screening for fetuses diagnosed with CCM. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.