EP04.14: Assessing the risk of early delivery in pregnant women with viral pneumonia due to COVID‐19

To identify the risk of early delivery in pregnant women with viral pneumonia due to COVID-19. For more than three years, all countries of the world lived in a pandemic caused by a new infection. Frequency of premature births has been discussed all this time. Retrospective cohort single-centre study was carried out in a tertiary level Covid hospital. Pregnant women were divided into 2 groups: 1 - delivered during treatment of viral pneumonia (n = 81); 2 - delivered after treatment of viral pneumonia (n = 69). Inclusion criteria: severe COVID-19 (positive laboratory test result), gestational age 22.0-41.6 weeks. Statistical analysis: Kaplan–Meier estimator, Mann-Whitney test. The groups differed in body mass index 30.0(27.0-32.0)kg in the 1st group, 27.0(24.0-30.2)kg in the 2nd; gestational age at the moment of hospitalisation 249(230-264) vs 203(179-228) days; number of days of illness preceding hospitalisation 7(5-10) vs 9(7-11) days (all p < 0.001). Clinical symptoms: only frequency of respiratory movements on admission differed 19(18-20) vs 18(18-19) (p = 0.004). Lung CT differed 55(45-75)% vs 35(25-45)% (p < 0.001). Laboratory parameters: level of D-dimer 1.4(0.9-1.9)μg/ml vs 0.9(0.6-1.6)μg/ml; level of C-reactive protein 86.1(59.7-141.3)mg/l vs 56.9(36.0-88.8)mg/l (both p < 0.001). Delivery period 254(233-265) vs 275(270-280) days (p < 0.001). Kaplan-Meier estimator was used to study delivery periods. Curves were plotted on the time interval from 154 days gestational age to the maximum period of delivery in days (see figure 1). The data obtained indicate the necessity of an early decision about hospitalisation of patients to select further treatment tactics, observation and delivery. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.