EP05.13: Fetal choroid plexus cysts: case series

To evaluate the prevalence and significance of fetal choroid plexus cysts (CPC) detected on screening ultrasound (US) scans. Retrospective, longitudinal study, carried out over 3 years period. Fetuses with CPC discovered at first trimester US were investigated. Structural/chromosomal anomaly rates and perinatal outcomes were analysed. SPSS programme was used to analyse the data. Among the 1372 first trimester US carried out during the period of study, 37 CPCs (2.6%) have been detected. Average echographic term of diagnosis was of 13 weeks + 4 days. In 31 fetuses, CPC was isolated (83.7%), and fetal karyotype was normal in 96.7% of the cases (30/31). Only one case of trisomy 18 has been confirmed. In 6 fetuses, additional abnormalities have been detected (16.2%). The most frequent ones was bilateral ventricumomegaly. Karyotype was normal in 16.6% of the cases (1/6). It confirmed the existence of trisomy 18 in all the 83,4% other cases (5/6). A therapeutic termination of pregnancy was carried out in all cases where karyotype confirmed aneuploidy's existence. Examination of the fetus confirmed the prenatal diagnosis. Normal postnatal anatomic findings was found in all cases of normal karyotype. In our study population, the prevalence of trisomy 18 in case of isolated fetal KPC was 3.2%, and 83.4% in case of additional abnormalities. Although there is a clear association between fetal CPC and trisomy 18, amniocentesis or chorionic villus sampling should be reserved for patients with US evidence of additional abnormalities.