Exploring the Distribution of Low Molecular Weight Compounds in Water-Based Two-Phase Systems with Various Salt Additives

The partition coefficients of seven low molecular weight compounds were tested in different aqueous two-phase systems. The ionic composition of each system included specific salt additives, and it was found that there is a linear relationship between the solute partition coefficients and the presence of different salt additives. The study suggests that the solute structure and the type of ions influence the solute response to the ionic environment. Additionally, it was observed that the solutes’ polar surface area and the solvent-accessible surface area are the essential structural features governing partitioning in aqueous two-phase systems.