Association of Methylenetetrahydrofolate Reductase (MTHFR) Polymorphism with Osteosarcoma in a Mexican Population
The methylenetetrahydrofolate reductase (<i>MTHFR</i>) gene 677C➔T polymorphism is capable of altering folate metabolism and can modify certain neoplasia risk. Reports have suggested that folate can have an influence on bone development and so it is of interest to know if the <i>MTHFR</i> 677C➔T polymorphism is associated with the malignant transformation process of this tissue. The polymorphism was determined in 55 patients with osteosarcoma and in 180 healthy individuals. Compared with C/T+C/C genotypes, a 3.7-fold reduction in osteosarcoma probability is possible with the T/T genotype (OR 0.27, CI 95% 0.07-0.82). Undoubtedly, further studies, utilizing large samples and carried out on different populations, are necessary to confirm these results.
Authors
- Irma G. Enríquez-Maldonado (ORCID: https://orcid.org/0009-0001-4327-0989)
- Iram Pablo Rodriguez-Sanchez (ORCID: https://orcid.org/0000-0002-5988-4168)
- Karmina Sánchez‐Meza (ORCID: https://orcid.org/0000-0002-8702-0252)
- Idalia Garza‐Veloz (ORCID: https://orcid.org/0000-0002-6307-1696)
- Rocio Ortı́z-López (ORCID: https://orcid.org/0000-0002-7783-026X)
- Augusto Rojas-Martı́nez (ORCID: https://orcid.org/0000-0003-3765-6778)
- Iván Delgado‐Enciso (ORCID: https://orcid.org/0000-0001-9848-862X)
- Daniel A. Montes-Galindo (ORCID: https://orcid.org/0000-0003-2748-4327)
- Carmen A. Sánchez-Ramírez (ORCID: https://orcid.org/0000-0002-3525-7821)
- Ángel Zavala-Pompa
- Alejandra E. Hernández-Rangel (ORCID: https://orcid.org/0009-0006-2626-7776)
- Margarita L. Martínez‐Fierro (ORCID: https://orcid.org/0000-0003-1478-9068)
- Alejandrina Rodríguez‐Hernández (ORCID: https://orcid.org/0000-0003-4267-0224)
- Jesus Ojeda-Ibarra
Institutions
- Mexican Social Security Institute (MX)
- Universidad Autónoma de Nuevo León (MX)
- Florida International University (US)
- Universidad Autónoma de Zacatecas "Francisco García Salinas" (MX)
- Universidad de Colima (MX)
- Tecnológico de Monterrey (MX)
Publication Details
- Journal
- Pediatric Reports
- Published
- 2024-09-09
- DOI
- https://doi.org/10.3390/pediatric16030066
- Primary Topic
- Folate and B Vitamins Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Universidad de Colima
- Instituto Mexicano del Seguro Social