EP16.02: Case report: gestational choriocarcinoma FIGO Stage III, score 8 (high‐risk) in 38‐year‐old woman four weeks' postpartum

Choriocarcinoma, a subtype of malignant gestational trophoblastic neoplasia, is a rare and aggressive disease. It can be divided into a gestational and non-gestational form with different biological activity, genotype and prognosis. A 38-year-old woman (2 Gravida 2 Para) presented at our clinic four weeks after delivery with persistent vaginal bleeding and decreasing hemoglobin to 6.8 mg/l. On ultrasound examination retained placental products were suspected. Since conservative management with Misoprostol was not effective, a curettage was performed. The histopathological result revealed a gestational choriocarcinoma invading the myometrium (CK18 positive, HPL positive, beta-hCG positive, p63 negative, PLAP positive, Ki67 (MIB-1) >80%). Beta-hCG was > 50 000 IU/l. The computed tomography (CT) scan revealed bilateral pulmonary metastases in the lungs. A multi-drug chemotherapy after EMACO-regimen was started 9.5 weeks postpartum during 14 days for seven cycles. The patient has been in tumour remission since then. This case report emphasises the differential diagnoses of vaginal intra- or postpartum bleeding. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.