OC17.06: *First trimester cardiac function in women with and without high risk of pre‐eclampsia

To examine the presence of cardiac dysfunction parameters or risk factors in the first trimester of pregnancy in women with and without high-risk of PE according to first trimester screening. Prospective cohort study of pregnant women with high-risk of PE and controls, recruited after first trimester screening, between 14 and 16 weeks. High-resolution images of the maternal heart were acquired, for echocardiographic parameter measurement and post-processing analysis, including myocardial strain analysis by 2D speckle-tracking. Angiogenic factors and CV laboratory biomarkers were also measured. Associations between study group and current CV evaluation parameters were evaluated. 322 women, 86 controls and 224 women at high-risk for PE, were included. As expected, there were significant differences in parameters associated with high-risk of PE such as blood pressure, body mass index and maternal age. Significant differences were also found in basal echocardiographic parameters, lipid profile and cardiac biomarkers (see table 1). CVD risk factors are present in the first trimester in women with high-risk pf PE. These findings suggest that cardiac changes that condition future CVD in these women may be present before developing clinical PE during pregnancy.