EP07.41: Congenital tumours: malformation and variable anatomy registry case series

To search for congenital tumours in malformation and variable anatomy registry (MALFOVAR) in order to summarise types and burdens of congenital tumours. MALFOVAR is a multicentric multimodality registry situated in Budapest Hungary which is dedicated to the detection of congenital malformations. The multicentre registry includes Semmelweis University, Heim Pal National Children Hospital, National Institute of Neuroscience (OMIII) and MIND clinic. We searched the MALFOVAR registry for congenital tumours in the period between the years 2007-2024. Altogether 613 cases were searched for congenital tumours. We found a total of 30 cases which had congenital tumours. Concerning localisation, most tumours were localised in the face and neck and thorax. Some tumours had extended to multiple areas. Some tumours were detected as a systemic disease or as a multiorgan manifestation as in tuberous sclerosis. Concerning histology type: Two cases of aggressive malignant tumours were detected which had caused death of the newborns within the first month of life: melanoma and sarcoma. Further six cases of lymphatic cystic tumours were found. In the thorax, we detected nine cases: 3 CPAM, 3 sequestrations, two cystic structures and one case of neuroblastoma (diagnosis was altered after delivery initially assessed as CPAM). Other cases were detected of: Rhabdomyoma, tuberous sclerosis (4), mesenchymal tumour (1), Arachnoid cyst (1), Hand AVM (1), Thymus hyperplasia (1), Nasal Glial heterotopy (1). Congenital tumours are extremely rare and come from diverse types of histology. In very rare instances malignant tumours can be found (such as melanoma and sarcoma) and result in devastating effects on the newborn and parents. Early recognition of tumours is of importance in order to plan treatment of tumour after delivery by operation or embolisation. Multimodality harmonisation (US and MRI) is of superior value in the detection and assessment of fetal tumours and specifically gives an added value in assessment of aggressivity of disease and detection of multiple localisation of the disease.