EP17.39: First trimester placental volume correlation with uterine and fetal blood flow in women managed for recurrent pregnancy loss: a preliminary study

To report preliminary study of using placental volume (PV) as a useful tool for diagnosing placentation failure in early stage in women with history of recurrent pregnancy loss due to antiphospholipid syndrome or thrombophilia. Prospective observational study including thirty patients with confirmative diagnosis of antiphospholipid syndrome or thrombophilia and on the therapeutic management. Placental volume measurement was obtained using VOCAL technique (30 degrees with six-step manual trace measurement) at 13-14 weeks of gestation. Doppler flow (uterine radial artery, uterine artery, and ductus venosus), placental weight, and birthweight were analysed for the correlation with placental volume. Second and third trimester placental infarct appearance, signs for fetal hypoxia (cerebroplacental ratio), incidence of fetal growth restriction and stillbirth were also taken into account. PV was shown to have an inverse correlation with uterine radial artery and uterine artery resistance (P < 0.05) but showed no correlation with ductus venosus. We are still waiting for the results of other variables. Placental volume in the late first trimester (13-14 weeks) was found to be related to uterine blood flow but not to fetal blood flow. This study will continue to investigate placental volume measurement for predicting pregnancy outcomes in patients with recurrent pregnancy loss due to antiphospholipid syndrome and thrombophilia.