Epitranscriptomic regulation of lipid oxidation and liver fibrosis via ENPP1 mRNA m6A modification
We describe a novel mechanism in which WTAP catalyzes m<sup>6</sup>A methylation of ENPP1 in a YTHDF1-dependent manner to enhance lipid oxidation, promoting HSCs proliferation and migration and liver fibrosis.
Authors
- Chao Lu (ORCID: https://orcid.org/0000-0003-4650-459X)
- Hui Tao (ORCID: https://orcid.org/0000-0003-3761-8659)
- Feng Sun
- Juan Wang (ORCID: https://orcid.org/0000-0002-2085-3727)
- Jingjing Yang (ORCID: https://orcid.org/0000-0002-3106-3798)
- Wei Hu (ORCID: https://orcid.org/0000-0002-8819-4641)
- Yang Yang (ORCID: https://orcid.org/0009-0007-3848-8936)
- Qi-Qi Dong
- Jia Lin
Institutions
- Anhui University of Science and Technology (CN)
- Anhui Medical University (CN)
- Second Affiliated Hospital of Anhui Medical University (CN)
- Nanjing University (CN)
Publication Details
- Journal
- Cellular and Molecular Life Sciences
- Published
- 2024-09-09
- DOI
- https://doi.org/10.1007/s00018-024-05420-y
- Citations
- 9
- Primary Topic
- RNA modifications and cancer
- Type
- article
- Field-Weighted Citation Impact
- 2.10
Funders
- National Natural Science Foundation of China