OP05.09: Diagnostic accuracy of cerebroplacental ratio in predicting perinatal outcome in uncomplicated pregnancies

Cerebroplacental ratio (CPR) has been claimed as independent predictor of adverse perinatal outcome in pregnancies complicated by fetal growth restriction (FGR). However, its use in pregnancies non complicated by FGR is controversial. The main aim of this systematic review was to report the strength of association and the predictive accuracy of CPR in predicting adverse perinatal outcome in pregnancies non complicated by FGR. Medline, Embase and Cinahl databases were searched up to February 2024. The primary outcome was to elucidate the strength of association between CPR and a composite score of adverse perinatal outcome including either perinatal death, operative vaginal delivery or Caesarean section due to category III CTG, Apgar score < 7 at 5 minutes, need for ventilation admission to neonatal intensive care unit or abnormal acid base status. Random-effect meta-analysis of risk were sued to analyse the data. Three studies (1548 pregnancies were included). CPR was not associated with either composite adverse perinatal outcome (p = 0.542), operative vaginal delivery or Caesarean section due to category III CTG (p = 0.222), Apgar score < 7 at 5 minutes (p = 0.312), need for ventilation (p = 0.824) admission to NICU (p = 0.428) or abnormal acid base status (p = 0.412). Likewise, the diagnostic accuracy of this parameter was poor. CPR is not associated or predictive of adverse perinatal outcome in uncomplicated pregnancies.