Pharmacokinetics of Piperacillin–Tazobactam in Critically Ill Patients with Open Abdomen and Vacuum-Assisted Wound Closure: Dosing Considerations Using Monte Carlo Simulation
Despite a wide inter-individual variability, the influence of OA/VAC on piperacillin and tazobactam PK parameters is not straightforward. The use of a CL<sub>CR</sub>-pondered PTZ dosing regimen from 12 g/1.5 g/day to 20 g/2.5 g/day is needed to reach a PTA > 85%.
Authors
- Vincent Dubuisson (ORCID: https://orcid.org/0000-0003-3132-1686)
- Dominique Breilh (ORCID: https://orcid.org/0000-0002-3783-2797)
- Matthieu Biais (ORCID: https://orcid.org/0000-0002-4485-9058)
- Jesse Butruille (ORCID: https://orcid.org/0000-0001-6984-607X)
- Laurent Petit (ORCID: https://orcid.org/0000-0003-1530-5678)
- Alexandre Lannou
- C. Carrié (ORCID: https://orcid.org/0000-0003-2492-0349)
- Sophie Maingault
Institutions
- Université de Bordeaux (FR)
- Bordeaux Population Health (FR)
- Hôpital Pellegrin (FR)
Publication Details
- Journal
- Pharmaceutics
- Published
- 2024-09-09
- DOI
- https://doi.org/10.3390/pharmaceutics16091191
- Citations
- 1
- Primary Topic
- Antibiotics Pharmacokinetics and Efficacy
- Type
- article
- Field-Weighted Citation Impact
- 0.45