Evaluating Autologous Platelet Aggregate as a Scaffold in the Treatment of Human Permanent Molars With Pulpitis: A Case Series

This case series aims to investigate the radiographic and clinical results of pulpotomy using concentrated growth factor (CGF), a scaffold obtained from the host, on adult human permanent molars. A total of four cases diagnosed with symptomatic reversible pulpitis based on history, clinical examination, and investigation were planned for CGF pulpotomy. Blood required for the procedure was collected in a 10 ml test tube without anticoagulants to produce CGF. Subsequently, the sample was promptly centrifuged using a tabletop centrifuge. The clot-free pulp chamber was then shielded with a small CGF membrane fragment. A layer of mineral trioxide aggregate (MTA), approximately 2 mm thick, was applied over the CGF membrane. Following this, the tooth was temporized with glass ionomer cement. The patients were scheduled for a follow-up visit after a day to assess postoperative discomfort and to proceed with the final composite restoration. All the patients were recalled at 6 and 12 months for follow-up. Three of the patients were clinically and radiographically asymptomatic following the treatment. The tooth demonstrated a normal periodontal ligament space on radiographic inspection, and it passed pulp sensibility tests. One patient, though, complained of excruciating discomfort 24 hours after the procedure. The favorable results of the three instances imply that more investigation is required to validate the application of this biocompatible alternative to the management of pulpitis in permanent human molar teeth. More research with larger sample numbers and longer recollection periods is required. The use of concentrated growth factor (CGF), derived from the patient's own blood, serves as an excellent biological scaffold for the treatment of pulpal diseases.