Impaired calcium influx underlies skewed T helper cell differentiation in children with <scp>IgE</scp>‐mediated food allergies
In children with IgE-mediated food allergies, dysregulation of T helper cell development is associated with impaired SOCE, which underlies an intrinsic impairment in Th1 and Treg differentiation. Along with tacrolimus-induced Th2 skewing, this highlights an important role of SOCE/calcineurin pathway in T helper cell differentiation.
Authors
- Michael R. Gold (ORCID: https://orcid.org/0000-0003-1222-3191)
- Peter Hsu (ORCID: https://orcid.org/0000-0003-4620-073X)
- Debra J. Palmer (ORCID: https://orcid.org/0000-0003-2498-8343)
- Dianne E. Campbell (ORCID: https://orcid.org/0000-0002-0907-6963)
- Ralph Nanan (ORCID: https://orcid.org/0000-0002-1749-6378)
- Brigitte Santner‐Nanan
- Susan L. Prescott (ORCID: https://orcid.org/0000-0003-4845-8590)
- Maria Makrides (ORCID: https://orcid.org/0000-0003-3832-541X)
- Ching‐Lung Lai (ORCID: https://orcid.org/0000-0002-5927-2436)
- P. J. Maltese
- Caroline Ong
Institutions
- The University of Sydney (AU)
- The Kids Research Institute Australia (AU)
- The University of Western Australia (AU)
- Princess Margaret Hospital for Children (AU)
- Nepean Hospital (AU)
- Children's Hospital at Westmead (AU)
- South Australian Health and Medical Research Institute (AU)
- Murdoch Children's Research Institute (AU)
- The University of Adelaide (AU)
Publication Details
- Journal
- Allergy
- Published
- 2024-09-09
- DOI
- https://doi.org/10.1111/all.16310
- Citations
- 1
- Primary Topic
- Food Allergy and Anaphylaxis Research
- Type
- article
- Field-Weighted Citation Impact
- 0.38
Funders
- Sanofi
- Swisse Wellness
- Medical Research Council
- National Health and Medical Research Council
- Agenzia Italiana del Farmaco, Ministero della Salute