Clinical Interest in Exome-Based Analysis of Somatic Mutational Signatures for Non-Small Cell Lung Cancer
Exome sequencing offers valuable insights into somatic mutational signatures in NSCLC. This study identified specific signatures associated with a poor response to immune checkpoint inhibitor (ICI) therapy and chemotherapy, potentially aiding treatment selection and identifying patients unlikely to benefit from these approaches.
Authors
- Caroline Truntzer (ORCID: https://orcid.org/0000-0003-0895-4813)
- Nicolas Roussot (ORCID: https://orcid.org/0000-0002-6562-6827)
- Hugo Mananet
- François Ghiringhelli (ORCID: https://orcid.org/0000-0002-5465-8305)
- Courèche Kaderbhaï
- Valentin Dérangère (ORCID: https://orcid.org/0000-0002-6311-5628)
- Morgane Peroz
Institutions
- Inserm (FR)
- Université de Bourgogne (FR)
- Centre Georges François Leclerc (FR)
Publication Details
- Journal
- Cancers
- Published
- 2024-09-09
- DOI
- https://doi.org/10.3390/cancers16173115
- Primary Topic
- Cancer Genomics and Diagnostics
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Université de Franche-Comté