Clinicopathological Factors Predicting Pathological Complete Response to Neoadjuvant Anti-HER2 Therapy in HER2-Positive Breast Cancer
A pCR after NAC impacts patient prognosis and influences the choice of adjuvant treatment for HER2+ breast cancer. Clinicopathological factors can help predict responses to HER2-targeted NAC. In our study, pre-ER/PR negativity, high pre-HER2 levels, and normal CA 15-3 levels were found to be potential predictors of pCR. These findings may contribute to developing more effective treatment strategies for HER2+ breast cancer.
Authors
- Jae Joon Kim (ORCID: https://orcid.org/0000-0003-4581-4115)
- Ki Seok Choo (ORCID: https://orcid.org/0000-0001-5072-4259)
- Seungju Lee (ORCID: https://orcid.org/0000-0001-5100-0017)
- Kyung Jin Nam (ORCID: https://orcid.org/0000-0001-5118-1903)
- Ji Hyeon Joo (ORCID: https://orcid.org/0000-0001-9275-3197)
- Jee Yeon Kim (ORCID: https://orcid.org/0000-0002-0503-984X)
- Hyun Yul Kim (ORCID: https://orcid.org/0000-0001-7717-7734)
- Youn Joo Jung (ORCID: https://orcid.org/0000-0002-1311-4950)
- Seok Kyeong Kang
Institutions
- Pusan National University Yangsan Hospital (KR)
Publication Details
- Journal
- Oncology
- Published
- 2024-09-09
- DOI
- https://doi.org/10.1159/000541019
- Primary Topic
- HER2/EGFR in Cancer Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Pusan National University