Comparative analysis of in situ and ex situ postmortem brain <scp>MRI</scp>: Evaluating volumetry, <scp>DTI</scp>, and relaxometry
The results of this study show that the volumes and MRI parameters of several brain regions are potentially affected by tissue extraction and subsequent formalin fixation, suggesting that methodological alterations are present in ex situ MRI. To avoid overlap of indistinguishable methodological and disease-related changes, we recommend performing in situ postmortem MRI as an additional intermediate step for in vivo MRI biomarker validation.
Authors
- Dominique Neuhaus (ORCID: https://orcid.org/0000-0002-1763-0661)
- Tanja Haas (ORCID: https://orcid.org/0000-0003-3287-3378)
- Thomas L. Rost (ORCID: https://orcid.org/0000-0002-0828-4330)
- Katja Schulze (ORCID: https://orcid.org/0000-0003-3704-5651)
- Eva Scheurer (ORCID: https://orcid.org/0000-0002-2742-0422)
- Regina Schlaeger (ORCID: https://orcid.org/0000-0003-2056-5765)
- Maria Janina Wendebourg (ORCID: https://orcid.org/0000-0003-4812-8807)
- Claudia Lenz (ORCID: https://orcid.org/0000-0001-5456-618X)
Institutions
- University of Basel (CH)
- University Hospital of Basel (CH)
Publication Details
- Journal
- Magnetic Resonance in Medicine
- Published
- 2024-09-09
- DOI
- https://doi.org/10.1002/mrm.30264
- Citations
- 1
- Primary Topic
- Advanced Neuroimaging Techniques and Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.40
Funders
- Neuromuscular Research Association Basel