Virulence gene polymorphisms in Shandong Helicobacter pylori strains and their relevance to gastric cancer
CagA proteins possessing CM motif pattern D were more frequently observed in patients with GC (P < 0.01), implying a potentially higher virulence of CM motif pattern D than the other CM motif patterns. Moreover, a strong positive association was identified between the vacA c1 genotype and GC, indicating that the vacA c1 genotype is a robust risk indicator for GC among male patients aged ≥55 years in Shandong.
Authors
- Youjun Wang (ORCID: https://orcid.org/0000-0003-0961-1716)
- Yan Zheng (ORCID: https://orcid.org/0000-0003-0165-0999)
- Yanran Li (ORCID: https://orcid.org/0009-0009-9263-6789)
- Xinyu Yang (ORCID: https://orcid.org/0000-0002-2194-4137)
- Yanan Gong (ORCID: https://orcid.org/0000-0002-6700-2399)
- Ruyue Fan (ORCID: https://orcid.org/0000-0002-5958-6128)
- Fengyan Pei
- Qing Chen (ORCID: https://orcid.org/0000-0001-9039-6886)
- Jianzhong Zhang (ORCID: https://orcid.org/0000-0001-7056-8206)
- Weijia Li (ORCID: https://orcid.org/0000-0002-6578-3152)
- Zhijing Xue (ORCID: https://orcid.org/0000-0002-9459-6663)
- Guohai Su (ORCID: https://orcid.org/0000-0003-4858-2647)
- Hailing Ding
- Fang Wang
Institutions
- Qilu University of Technology (CN)
- Jinan Central Hospital (CN)
- National Institute for Communicable Disease Control and Prevention (CN)
- Qilu Hospital of Shandong University (CN)
- Shandong First Medical University (CN)
- Shandong Center for Disease Control and Prevention (CN)
Publication Details
- Journal
- PLoS ONE
- Published
- 2024-09-09
- DOI
- https://doi.org/10.1371/journal.pone.0309844
- Citations
- 7
- Primary Topic
- Helicobacter pylori-related gastroenterology studies
- Type
- article
- Field-Weighted Citation Impact
- 4.01
Funders
- Natural Science Foundation of Shandong Province
- National Science and Technology Major Project
- Science and Technology Development Plan of Shandong Province