Optimization of <sup>1</sup>H‐MRS methods for large‐volume acquisition of low‐concentration downfield resonances at <scp>3 T</scp> and 7 T
Improved spectral quality with higher downfield signal, shorter TE, lower nuisance signal, reduced artifacts, and narrower peaks was realized at 7 T. These methodological improvements allowed for previously unachievable detection of NAD<sup>+</sup> and tryptophan in human brain at 3 T in under 5 min.
Authors
- Sophia Swago (ORCID: https://orcid.org/0000-0001-8334-4746)
- Ravi Prakash Reddy Nanga (ORCID: https://orcid.org/0000-0002-3644-5656)
- Ravinder Reddy (ORCID: https://orcid.org/0000-0003-4580-2392)
- Walter R T Witschey (ORCID: https://orcid.org/0000-0003-1669-2120)
- Mark A. Elliott (ORCID: https://orcid.org/0000-0003-2560-8760)
- Neil Wilson (ORCID: https://orcid.org/0009-0002-7766-2929)
Institutions
- University of Pennsylvania (US)
Publication Details
- Journal
- Magnetic Resonance in Medicine
- Published
- 2024-09-09
- DOI
- https://doi.org/10.1002/mrm.30273
- Citations
- 3
- Primary Topic
- Advanced MRI Techniques and Applications
- Type
- article
- Field-Weighted Citation Impact
- 1.21
Funders
- National Institutes of Health
- National Institute on Aging
- National Heart, Lung, and Blood Institute
- National Institute of Biomedical Imaging and Bioengineering