Datopotamab Deruxtecan Versus Docetaxel for Previously Treated Advanced or Metastatic Non–Small Cell Lung Cancer: The Randomized, Open-Label Phase III TROPION-Lung01 Study
Dato-DXd significantly improved PFS versus docetaxel in patients with advanced/metastatic NSCLC, driven by patients with nonsquamous histology. OS showed a numerical benefit but did not reach statistical significance. No unexpected safety signals were observed.
Authors
- Federico Cappuzzo (ORCID: https://orcid.org/0000-0002-6295-6767)
- Gee-Chen Chang
- Kadoaki Ohashi (ORCID: https://orcid.org/0000-0002-5180-3933)
- Satoshi Sakaguchi (ORCID: https://orcid.org/0000-0002-8916-636X)
- Filippo de Marinis (ORCID: https://orcid.org/0000-0002-1118-5536)
- Chee‐Seng Tan (ORCID: https://orcid.org/0000-0003-2474-6942)
- Shun Lü (ORCID: https://orcid.org/0000-0001-8833-7262)
- Ki Hyeong Lee (ORCID: https://orcid.org/0000-0002-7830-5950)
- Ryo Ko (ORCID: https://orcid.org/0000-0002-2551-3529)
- Benjamin Shieh
- Óscar Juan (ORCID: https://orcid.org/0000-0002-7772-9030)
- Yuichi Tambo (ORCID: https://orcid.org/0000-0002-4095-4533)
- Elvire Pons‐Tostivint (ORCID: https://orcid.org/0000-0003-4478-0523)
- Byoung Yong Shim (ORCID: https://orcid.org/0000-0001-6473-786X)
- Min Hee Hong (ORCID: https://orcid.org/0000-0003-3490-2195)
- Francisco Javier Ramírez Godinez
- Masashi Kondo (ORCID: https://orcid.org/0000-0001-8818-8316)
- Gaëtan Catala (ORCID: https://orcid.org/0000-0003-2483-4977)
- Rodryg Ramlau (ORCID: https://orcid.org/0000-0002-3199-2298)
- Paul Howarth (ORCID: https://orcid.org/0000-0001-8401-2081)
- Akin Atmaca
- Fabio M. Gomes (ORCID: https://orcid.org/0000-0001-8439-8762)
- Céline Mascaux
- Juergen Wolf (ORCID: https://orcid.org/0000-0001-8833-8812)
- Michael Chargualaf (ORCID: https://orcid.org/0000-0002-1040-9470)
- Manuel Cobo (ORCID: https://orcid.org/0000-0003-3402-1144)
- Naveen S. Basappa (ORCID: https://orcid.org/0000-0002-3163-9902)
- Е. V. Ledin
- Yu‐Feng Wei (ORCID: https://orcid.org/0000-0002-6380-3527)
- Froylán López-López
- Jaafar Bennouna (ORCID: https://orcid.org/0000-0002-5034-1108)
- T. Mansy
- Denis Moro‐Sibilot (ORCID: https://orcid.org/0000-0001-6776-8610)
- Mirelis Acosta-Rivera
- Stefania Salvagni
- Robert Mróz (ORCID: https://orcid.org/0000-0002-5826-7395)
- Hiroshi Tanaka (ORCID: https://orcid.org/0000-0001-7057-813X)
- Claudia Proto (ORCID: https://orcid.org/0000-0003-0287-9787)
- Yasushi Goto (ORCID: https://orcid.org/0000-0002-7437-5054)
- Myung‐Ju Ahn (ORCID: https://orcid.org/0000-0002-5740-9654)
- Yu Yao (ORCID: https://orcid.org/0000-0002-8366-4712)
- Motohiro Tamiya (ORCID: https://orcid.org/0000-0001-6529-3092)
- Ferdinando Cerciello (ORCID: https://orcid.org/0000-0001-8987-5732)
- Hidetoshi Hayashi (ORCID: https://orcid.org/0000-0001-8787-5587)
- H. Léna
- W.C. Chang (ORCID: https://orcid.org/0000-0001-9065-8954)
- M. Pérol
- Satoshi Oizumi (ORCID: https://orcid.org/0000-0002-9742-1818)
- Benjamin Solomon (ORCID: https://orcid.org/0000-0003-3059-5730)
- Sang‐We Kim (ORCID: https://orcid.org/0000-0003-1065-8095)
- Sebahat Ocak (ORCID: https://orcid.org/0000-0002-7894-1113)
- Héctor Soto Parrà (ORCID: https://orcid.org/0000-0001-7966-4472)
- Tsung‐Ying Yang (ORCID: https://orcid.org/0000-0003-0198-1077)
- Melissa L. Johnson (ORCID: https://orcid.org/0000-0001-9874-1314)
- Robin Cornelissen (ORCID: https://orcid.org/0000-0002-4289-3092)
- Luis Paz‐Ares (ORCID: https://orcid.org/0000-0002-1947-3364)
- Kiyotaka Yoh (ORCID: https://orcid.org/0000-0001-6928-357X)
- Elena Poddubskaya (ORCID: https://orcid.org/0000-0001-6476-6337)
- Jacob M. Sands (ORCID: https://orcid.org/0000-0003-4663-7464)
- Julien Mazières (ORCID: https://orcid.org/0000-0002-5921-7613)
- Satoru Kitazono (ORCID: https://orcid.org/0000-0001-7371-2787)
- Margarita Majem (ORCID: https://orcid.org/0000-0002-9919-7485)
- Daniel Brungs (ORCID: https://orcid.org/0000-0002-8154-6966)
- Takayasu Kurata (ORCID: https://orcid.org/0000-0003-4123-3567)
- Laurent Greillier (ORCID: https://orcid.org/0000-0002-5807-9503)
- Bruno Fang (ORCID: https://orcid.org/0009-0004-7703-2366)
- Jerónimo Rafael Rodríguez Cid
- Sujith Kalmadi
- Christos S. Karapetis (ORCID: https://orcid.org/0000-0003-1741-996X)
- Deise Uema (ORCID: https://orcid.org/0000-0002-6883-6678)
- Dariusz M. Kowalski (ORCID: https://orcid.org/0000-0002-9452-3229)
- Niels Reinmuth (ORCID: https://orcid.org/0000-0002-7369-4512)
- Richard D. Hall (ORCID: https://orcid.org/0000-0001-5812-8857)
- José Fuentes Pradera
- Toshiyuki Kozuki (ORCID: https://orcid.org/0000-0001-8432-8975)
- Christian Schumann (ORCID: https://orcid.org/0000-0001-8143-5978)
- Hideaki Mizutani
- Aaron Elliott Lisberg (ORCID: https://orcid.org/0000-0003-3048-4352)
- Haruko Daga (ORCID: https://orcid.org/0000-0002-5191-6233)
- Dolores Isla (ORCID: https://orcid.org/0000-0002-2483-198X)
- Manuel Dómine (ORCID: https://orcid.org/0000-0002-1128-434X)
- Shunichi Sugawara (ORCID: https://orcid.org/0000-0002-3427-4558)
- Balázs Halmos (ORCID: https://orcid.org/0000-0001-7548-8360)
- Mariano Provencio (ORCID: https://orcid.org/0000-0001-6315-7919)
- Christine Greil (ORCID: https://orcid.org/0000-0002-2544-6952)
- Andrea Veatch
- Anna Łowczak (ORCID: https://orcid.org/0000-0001-5512-9512)
- Tirrell Johnson
- Sagun Parakh (ORCID: https://orcid.org/0000-0003-3891-2489)
- Gastón Lucas Martinengo
- Noemı́ Reguart (ORCID: https://orcid.org/0000-0001-8190-499X)
- Cheol Park (ORCID: https://orcid.org/0000-0002-0486-9542)
- Csaba Böcskei
- Ines B. Menjak (ORCID: https://orcid.org/0000-0002-4239-0858)
- Milada Zemanová (ORCID: https://orcid.org/0000-0002-1904-1035)
- Enriqueta Felip (ORCID: https://orcid.org/0000-0002-7620-0098)
- Nicolas M Girard (ORCID: https://orcid.org/0000-0001-9909-2299)
- Jos A. Stigt
- Marina Chiara Garassino (ORCID: https://orcid.org/0000-0002-3821-5598)
- Adnan Nagria
- Yong Zhang (ORCID: https://orcid.org/0009-0004-8865-905X)
- Janusz Milanowski (ORCID: https://orcid.org/0000-0002-8616-596X)
- Jin-Soo Kim (ORCID: https://orcid.org/0000-0003-3369-2974)
- Jialei Wang (ORCID: https://orcid.org/0000-0001-9977-2219)
- Geoffrey Liu (ORCID: https://orcid.org/0000-0002-2603-7296)
- Jin-Hyoung Kang
- Kentaro Tanaka (ORCID: https://orcid.org/0000-0003-4602-4465)
- Hongmei Sun (ORCID: https://orcid.org/0000-0003-1383-5720)
- Se Hyun Kim (ORCID: https://orcid.org/0000-0001-7078-2835)
- Amit Jain (ORCID: https://orcid.org/0000-0003-3594-9374)
- Bo Gao (ORCID: https://orcid.org/0000-0003-3461-0096)
- Ahad A. Sadiq
- Virginie Westeel (ORCID: https://orcid.org/0000-0003-2358-3694)
- Corinne Lamour
- Martin Früh
- Wen-Tsung Huang
- Thomas Wehler (ORCID: https://orcid.org/0000-0002-6918-654X)
- Tanya Ahmad
- Steven Gans
- Boon Yeow Daniel Chan
- James Ho
- Yee Soo Chae
- Feng Luo (ORCID: https://orcid.org/0009-0006-9343-0721)
- Silvia Novello
- Chien-Chung Ling
- Frédéric Forget
- Manlio Mencoboni
- Maria Carmen Areses
- William Lawler
- H Ozasa
- Juan Puig
- Yun Gyoo Lee
- Débora S. Bruno
- David Vicente Baz (ORCID: https://orcid.org/0000-0002-6832-9705)
- Khawaja Jahangir
- Michael Castine
Institutions
- Universitat Autònoma de Barcelona (ES)
- University of California, Los Angeles (US)
- Shanghai Jiao Tong University (CN)
- University of Wollongong (AU)
- University of Virginia Health System (US)
- Severance Hospital (KR)
- Samsung Medical Center (KR)
- Shanghai Chest Hospital (CN)
- Hospital Universitari i Politècnic La Fe (ES)
- Centre Hospitalier Universitaire de Nantes (FR)
- University of Chicago (US)
- Hospital Universitario Virgen Macarena (ES)
- Kindai University Hospital (JP)
- Kyushu University Hospital (JP)
- Hospital Universitario 12 De Octubre (ES)
- Centre Léon Bérard (FR)
- Dana-Farber Cancer Institute (US)
- The Cancer Institute Hospital (JP)
- Hôpitaux Universitaires de Strasbourg (FR)
- Erasmus MC Cancer Institute (NL)
- Daiichi Sankyo (United States) (US)
- Instituto de Investigación Biomédica de Málaga (ES)
- Sendai Kousei Hospital (JP)
- Japanese Foundation For Cancer Research (JP)
- Institut Curie (FR)
- Sungkyunkwan University (KR)
Publication Details
- Journal
- Journal of Clinical Oncology
- Published
- 2024-09-09
- DOI
- https://doi.org/10.1200/jco-24-01544
- Citations
- 144
- Primary Topic
- Lung Cancer Treatments and Mutations
- Type
- article
- Field-Weighted Citation Impact
- 60.33
Funders
- Daiichi Sankyo Europe