Trastuzumab deruxtecan in patients with previously treated HER2-low advanced breast cancer and active brain metastases: the DEBBRAH trial

T-DXd demonstrated promising intracranial activity in pretreated HER2-low ABC patients with active BMs. Further studies are needed to validate these results in larger cohorts. This trial is registered with ClinicalTrials.gov, NCT04420598.

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Publication Details

Journal
ESMO Open
Published
2024-09-01
DOI
https://doi.org/10.1016/j.esmoop.2024.103699
Citations
29
Primary Topic
HER2/EGFR in Cancer Research
Type
article
Field-Weighted Citation Impact
8.19

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article

Trastuzumab deruxtecan in patients with previously treated HER2-low advanced breast cancer and active brain metastases: the DEBBRAH trial

A Llombart-Cussac, Daniel Alcalá-López, Sònia Servitja, Cristina Saavedra et al.
29 citations
ESMO Open
HER2/EGFR in Cancer Research
8.19
article

Trastuzumab deruxtecan in patients with previously treated HER2-low advanced breast cancer and active brain metastases: the DEBBRAH trial

A Llombart-Cussac, Daniel Alcalá-López, Sònia Servitja, Cristina Saavedra, Adela Fernández-Ortega, Sofía Braga, Laia Garrigós, Griselda Martrat, María Gión, Iris Teruel, Juan de la Haba-Rodríguez, Manuel Ruíz‐Borrego, Jhudit Pérez‐Escuredo, Javier Cortés, Marta Vaz Batista, Miguel Sampayo-Cordero, José Manuel Pérez-García, María Fernández, Patricia Cortez, A Martínez-Bueno
article en
29 citations

Abstract

T-DXd demonstrated promising intracranial activity in pretreated HER2-low ABC patients with active BMs. Further studies are needed to validate these results in larger cohorts. This trial is registered with ClinicalTrials.gov, NCT04420598.

ESMO OpenVol. 9(9)
Universidad de Alcalá (ES), Instituto Cajal (ES), Instituto Maimónides de Investigación Biomédica de Córdoba (ES), Instituto Oncológico Dr. Rosell (ES), Hospital Universitario Dexeus (ES), Hospital Prof. Dr. Fernando Fonseca (PT), MedSIR (Spain) (ES), Institut Català d'Oncologia (ES), Hospital Del Mar (ES), Badalona Serveis Assistencials (ES), Hospital Ruber Internacional (ES), Hospital Municipal de Badalona (ES), Hospital Universitario Virgen del Rocío (ES), Hospital Universitario Ramón y Cajal (ES), Universidad Europea de Madrid (ES)
AstraZeneca, Daiichi Sankyo Europe
Good health and well-being
Openalex Percentile: Top 2%
HER2/EGFR in Cancer Research
8.19
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