Low-Frequency, Sustained CD4 T-Cell Responses <i>Chlamydia trachomatis</i> in Women: Predominant Targeting of Chlamydial Proteaselike Activity Factor (CPAF)
Our results indicate that CT infection elicits low-frequency, persistent CD4 T-cell responses in most women and that the secreted protein, CPAF, is an immunoprevalent CT antigen. Altogether, these data support development and testing of CT vaccines that enhance CD4 T cells against CPAF.
Authors
- Catherine M. O’Connell (ORCID: https://orcid.org/0000-0002-8229-684X)
- Fiona Shaw
- Joanna Warren (ORCID: https://orcid.org/0000-0003-0595-0390)
- Genevieve Clutton (ORCID: https://orcid.org/0000-0001-5853-9509)
- Taylor B. Poston (ORCID: https://orcid.org/0000-0002-5985-4153)
- Harold C. Wiesenfeld (ORCID: https://orcid.org/0000-0002-6094-1238)
- Kacy S. Yount (ORCID: https://orcid.org/0000-0001-7050-0164)
- Shayla Z Conrad
- Nilu Goonetilleke (ORCID: https://orcid.org/0000-0003-2278-1656)
- Xiaojing Zheng (ORCID: https://orcid.org/0000-0003-2248-933X)
- Toni Darville
- Yanli Li (ORCID: https://orcid.org/0000-0001-6190-9849)
- Yinyan Xu (ORCID: https://orcid.org/0000-0002-8905-363X)
Institutions
- University of North Carolina at Chapel Hill (US)
- University of Pittsburgh (US)
- Magee-Womens Research Institute (US)
Publication Details
- Journal
- The Journal of Infectious Diseases
- Published
- 2024-09-09
- DOI
- https://doi.org/10.1093/infdis/jiae443
- Citations
- 7
- Primary Topic
- Reproductive tract infections research
- Type
- article
- Field-Weighted Citation Impact
- 2.07